【摘要】 <正> 国内某地是人原发性肝癌的高发地区。从动物肝病调查,发现当地畜禽(鸭、猪、牛)的肝病也很普遍,而且在鸭子和老母猪均检出原发性肝癌,其中特别是鸭肝癌的检出率极高,例如一次在该地区的两个公社随机取样剖检470只成年鸭,发现肝脏病变极为普遍,检出原发性肝癌11例,占2.4%。而且随着鸭龄的增长,肝癌的检出率更是大幅度增加,四年以上老鸭的肝癌检出率高达15%以上。根据流行病学调查结果,初步分析鸭肝癌的地区分布与人的肝癌之间存在一定的关更多还原

【Abstract】 In certain locality,where was a high incidence region of duck pr- imary liver cancer.The corn was used as a chief feed for these an- imals,and the contamination of fungi (Aspergillus flavus) and aflato- xins were more heavier in corn than the other foodstuffs in that re- gion. In order to evaluate the exact etiological factors of the duck liver cancer,the experiment have been conducted for the study of carcin- ogenic effect of the mouldy corn for thirty months.In this trail,3 groups of ducks were used:(1) 50 ducks fed mouldy corn,(2) 34 ducks fed a culture of A.flavus isolating from the mouldy corn,and (3) 30 ducks as control. It was found that mouldy corn contaminated with aflatoxins in the diet of ducks resulted in the induction of liver cancers.From the 16th. month of the carcinogenic experiment,in mouldy corn group there 12 cases of liver cancer were induced.Which include three types of liver cancer:5 cases of hepatocellular carcinomas,4 cholartgiocellular ca- rcinomas,and 3 mixed type hepatocarcinomas。 In the A.flavus culture group,after a period of 24 months,there were 3 cases of liver cancer induced,including 2 hepatocellular carc- inomas and one cholangiocellular carcinoma. It is apparent that the carcinogenic effect of the mouldy corn was more strong than the fungal cultures. The histological morphology of each type of the liver cancers were described in detail.The present investigation concluded that the mo- uldy corn seem to play the most important role in the causation of duck liver cancer in that region.更多还原