【摘要】 <正> 自1972年Magnius等在乙型肝炎表面抗原(HBsAg)阳性血清中发现HB_eAg系统以后,e抗原系统在流行病学及临床预后等方面的重要性日益受到重视,我们对e抗原系统在某些肝病及无症状HBsAg携带者中的分布情况做了一些调查,研究其临床意义,结果报告如后。更多还原

【Abstract】 The results of detecting HBeAg and anti-HBe in 376 patients with viral hepatitis of various clinical types and asymptomatic HBsAg carriers were described in the present study. The detective rate of HBsAg in hepatitis patients was 45.18%, and that of anti-HBs was 3.01%. Fourteen percent of the patients with HBsAg positive was HBeAg positive, and 21.33% was anti-HBe positive. HBeAg was not detected in HBsAg nagative patients, but anti-HBe was detected in four of them. HBeAg detective rate of chronic active hepatitis (20.93%) was highest among the patients with hepatitis of various clinical types, and anti-HBe detective rate (37.5%) of cirrhosis was highest. In addition, it was found that the detection of HBeAg and anti-HBe is relevant to the phase of the disease, the frequency of abnormal liver founction test and the titer of HBsAg in serum. The detective rates of HBeAg and anti-HBe in asymptomatic HBsAg carriers were 13.64% and 18.18% respectively. These results suggest that the presence of HBeAg indicates persistent HBV infection in the body with continuous activation and progression of the disease. But the presence of anti-HBe marks that the state of disease proceeds to stability or convalescence.更多还原