【摘要】 <正> 在《毒扁豆碱对大鼠电针镇痛作用的影响》一文中,我们初步提出了胆碱能神经在针刺镇痛中起着积极作用的看法,为了对此作进一步探讨,本文用直接给乙酰胆碱(ACh)或利用密胆碱(HC-3)阻断ACh合成以降低ACh的方法,观察ACh对电针镇痛作用的影响。更多还原

【Abstract】 According to the metabolic pathway fo cholinergic neurotransmitter,ACh and HC-3 were used as tools to raise or reduce the effective concentration of ACh respectively and their influence on the electroacupuncture analgesia was observed.It is found that:(1) The pain threshold of animals which had received an initial injection of eserine,followed by an additional administration of ACh was much higher than that of animals which had received only a single injection of eserine (P<0.001).But a small dose (100r/Kg) of the ACh injected intraventricularly alone could also cause an increase of pain threshold.(2) The effect of electroacupuncture analgesia became more obvious by injecting eserine and ACh simultaneously.(3) A significant decrease(46.38-50.84%,P<0.001) of ACh content in the hypothalamus and caudate nucleus occurred 4 h after an intraventricular injection of HC-3 (40μg).(4) In the animal receiving the intraventricular injection of HC-3,the pain threshold was lowered obviously (P<0.01)4h after injection.The effect of electroacupuncture analgesia and the analgesic effect of eserine plus electroacupuncture were completely inhibited.Furthermore this inhibitory effect could be reversed by an additional injection of ACh which might produce reappearance of the analgesic effect of electroacupuncture.From these observations,it is considered that the ACh (level) plays very important role in electroacupuncture analgesia.更多还原