【摘要】 常咯啉的化学名是4-{3′,5′双′[(N-吡咯烷基)甲基]-4-羟苯胺基}喹唑啉。兔和狗静注常咯啉后该药能提高电刺激所致的室颤阈值,室颤阈值提高与剂量有关。室颤阈值提高的发生时间,以静脉推注法为最快,而以滴注法的维持时间为最长,在给药完毕后50分钟,室颤阈值又回至给药前的水平。更多还原

【Abstract】 Changrolin,4-{3’,5’-bis[(N-pyrolidinyl)methyl]-4’-hydroxyanilino}-quina-zolin,raised the threshold of ventricular fibrillation elicited by repeated electri-cal stimulation in rabbits and dogs.This dose-related elevation of the fibrillationthrehold,occurred earlier after bolus injection,but lasted longer after drip infu-sion.The fibrillation threshold returned to the premedication level about 50minutes after the discontinuance of Changrolin.更多还原