【摘要】 本文报道应用国产厌气棒状杆菌菌苗局部注射和冷冻手术综合治疗晚期肿瘤10例,经过7～10个月随访,疗效显著。从切除标本的病理组织学检查,可见到癌肿坏死,癌巢周围有大量白细胞浸润,显示局部用药后明显地消除肿瘤的迹象。提示了这种方法能增强免疫作用,有效地控制肿瘤。更多还原

【Abstract】 Based on the concept that cancer is possibly a disease related to immunological disorder, corynebacterium anaerobic vaccine was used in combination with cryosurgery in 10 cases of disseminated cancer in the period between April and October 1978. The vaccine was injected into the tumor (intratumoral, I.T.) and started before, during or after cryosurgery, with a dosage of 4 mg I.T. once every week for 3 months, followed by 4 mg I.T. biweekly for a period of 1-2 years. All the patients were followed for 7-14 months and were alive, with 7 of them free of cancer clinically. In 2 cases, surgical operation was done during vaccine therapy. Pathological features in the resected specimens after intratumoral injection of vaccine were as follows: (1) marked necrosis of tumor tissue especially in the area where vaccine was injected. (2) remarkable white cell infiltration (including plasma cells and macrophages) at the site of necrosis. (3) residual tumor cells at the area of vaccine injection undergoing degenerative changes. It is postulated that combined cryosurgery and vaccine treatment may enhance both specific and non-specific immunity against cancer.更多还原