【摘要】 <正> 以往实验发现,采用接近临床针麻病人的刺激强度(弱电针),则静脉注射纳洛酮能部分翻转针刺镇痛效应;如果采用超强刺激(强电针)纳洛酮就难翻转。从动物行为来看,强电针是带有应激因素,应激镇痛时垂体分泌大量促肾上腺皮质激素(ACTH),去甲肾上腺素(NA)也增多,周围血液中ACTH、NA和环腺苷酸(cAMP)含量必然升高。为了更多还原

【Abstract】 Unilateral "Ho-Ku" and "Wei-Kuan" points of each rabbit were electrically needled. The acupuncture analgesia was induced by two different strengthes of stimulation. (1) A moderate strength stimulation which was sufficiant to cause moderate muscle twitching, but mild enough to keep the animal in quiet state; the stimulation current was about 12.5-17.5 mA. (loading 3 KΩ). (2) Superstrength stimulation which made the animals agitation and struggle, but the animals may become quiet gradually during the induction of acupuncture; stimulation current was about 25-30 mA (loading 3 KΩ).Our results showed: (1) At the 20th min. Of acupuncture, the increase rate of pain threshold. Of "superstrength electro-acupuncture" and "moderate strength electro-aoupunoture" were 150% and 140% respectively. There was no significant difference between these two groups. (2) The analgesic effect of "moderate strength electro-acupuncture" could be significantly reversed by naloxone (0.4 mg/kg 1. V. ). (3) During "moderate strength electro-acupuncture" analgesia, the plasma cortisol levels tended to decrease, and the plasma cAMP levels were markedly decreased (P<0.05). During"superstrength eleotro-aoupunoture"analgesia, there were a significant elevation of plasma cortisol and oAMP levels (P<0.05). There was no significant change neither the plasma oortisol nor cAMP levels in the control group.The present experimental results indicate that "superstrength electro-acupuncture" analgesia, had the similarities with "stress analgesia". In fact there is essential difference in the mechanism of the "acupuncture analgesia" and "stress analgesia".更多还原