【摘要】 <正> 近年来,研究冠心病药物的作用,通常从心脏功能、心脏血管及心肌缺血时的组织学和代谢变化等方面分别进行,无统一的筛选抗心肌缺血药的方法。由于开展了实验性心肌梗塞范围(以下简称心梗范围)的研究,已确立“缺血心肌是可以救活的”观点。现在心梗范围已成为研究药物疗效和作用机理常用指标。我们制成血液动力更多还原

【Abstract】 The effects of "Tanshinone IIA" sodium sulfonate (TS 201) on epioardial S-T Segment elevation, hemodynamio parameters and myooardial infarot extent (N-BT evaluation) were studied in 23 open-chest anesthetized dogs and compared with those of propranolol. During the acute stage (30 min) of infarction caused by ligating the left anterior descending coronary artery (LAD). TS 201 (2mg/kg, iv) exerted no significant effect on epicardial S-T segment elevation, heart rate, femoral arterial blood pressure and heart rate × mean blood pressure product, but showed a significant decrease in left ventricular end diastolio pressure. The ultimate infarct extent after 24 hours of infarction was significantly reduced by TS 201 (8 mk/kg, iv, in 4 divided doses). Propranolol was shown to protect the S-T segment elevation, exert significant negative chronotropic and inotropio effect during the acute stage of LAD ligation, and diminish the ultimate infarot extent of 24 hours significantly. These results illustrate that TS 201 may be one of the active principles of Salvia Miltirrhiza Bunge. The mechanism of protection by TS 201 on isohemio myocardium is now under our investigation.更多还原