【摘要】 <正> 深部真菌病是近代医学广泛应用化学治疗后的新问题,国内已有不少病理方面的报道。存在于自然界的真菌不下万种,而能致病的约有40余种,其中不少属条件致病菌,仅在机体免疫机能减退或局部组织抵抗力低下等情况下致病。本文报道我教研组82例深部真菌病尸检材料,并对其发病因素及病理变化进行探讨和分析,为深部真菌病的临更多还原

【Abstract】 From 1928 to 1977, 4532 consecutive autopsies had been done, and among them 82 oases were deep fungal infections. The incidence of this disease had 35.7 folds increasing during the latest few years, being 0.3% at 1951 - 1955 and 11.7% 1976-1977. Out of these 82 cases, 3 only were primary fungal infection while the rest, secondary to various bacterial invasions (25 cases), subaonte hepatitis (18 oases), hemopo-ietic diseases (15 oases), malignant tumors (7 oases) and miscellaneous (14 oases). Most of th.6 oases (98.4%) had received antibiotics during their course of illness and the incidence of deep fungal infection increased with the varieties of antibiotics used and the duration of treatment required. 90.6% cases received also oorticosteroids. The role and mechanism of antibiotics and corticosteroids in predisposing the patients to deep fungal infection were discussed.The diagnosis and classification were made mainly according to the morphology of the fungi found in tissue sections, however only 15 cases had antemortem or postmortem cultures recorded.Types of fungi in this series were aspergillosis (34 cases), oandidiasis (21 cases), muoormycosis (5 cases), cryptocoocosis (5 oases), torulopsiosis (1 case) and mixed infections of above species (16 oases). Morphological characteristics of these fungi, their prevalent localizations and pathologic changes were discribed, together with their differential diagnosis.更多还原