【摘要】 <正> 自从Bailey与Cushing(1926)发表中枢神经系统肿瘤的命名和分类以来,髓母细胞瘤已有许多报告,对这一肿瘤的组织结构和生物学特性进行了研究,特别是对组织结构和预后的关系方面存在分歧意见。本文通过对218例髓母细胞瘤的观察,分析其病理形态特征,并对鉴别诊断和它的生物学特性方面加以讨论。更多还原

【Abstract】 218 cases of medulloblastoma, verified pathologically during the period of 26 years (1951 - 1976) in Hua Shan Hospital, represented 4.4% of all CNS tumors, 5% of all intracranial tumors, and 12.3% of all gliomas. 154 of the 218 cases were males, 64 females. 91% of cases were below 20 years of age, 70% children less than 13 years-old, which accounted for 27% of all the tumors of CNS in childhood. The tumor was situated chiefly on the vermis and the hemisphere of cerebellum.The outstanding feature of the tumors was the presence of typical and atypical rosettes, which appeared in 158 of the 218 cases. These cellular patterns were considered to be of diagnostic significance. The arrangement of the tumor tissues presented three typos: diffuse, bunchy and mixed. In 118 of cases, the tumor cells of the medulloblostoma showed evidence of transition into neuroglias, and 40 of cases showed evidence of transition into neurons. In the rest 60 of cases, no such evidence was observed. 9 cases had shown clinical symptoms of spinal cord damage. Among them, 3 cases had been studied postmortemly, and the dissemination and the metastasis of tumors to the spinal cord and subarachnoid space were verified.The differential diagnosis between this tumor and gliomas, meningioma and microglioma were discussed.更多还原