【摘要】 5α-雄甾-3;17-双酮用节杆菌转化得到四个含9α-羟基的产物(2～5),其中△~1-5α-雄甾-9α-羟基-3,17-双酮为主要产物。它们的结构经光谱分析和化学方法测定。更多还原

【Abstract】 Incubation of 5α-androstane-3, 17-dione with Corynebacterium simplex afforded four 9α-hydroxylated produots (2～5), among which 9α-hydroxy-Δ~1-5α-androstene-3, 17-dione (3) was the major product. The structures of the four compounds were assigned by means of spectroscopic evidences and chemical correlations.It is known that the conversion of Δ~4-androstene-3, 17-dione by microorganism involves a 9α-hydroxylation, followed by a 1, 2-dehydrogenation (or vice versa) resulting in the formation of 9, 10-secophenol, but in the present case 9α-hydroxy-Δ~1-5α-androstane-3, 17-dione (3) was the major microbiological transformation product.更多还原