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用放射自显影术观察14C脒基硫脲在动物体内的分布和代谢

Observations of the distribution and metabolism of 14C-ASU in animal by autoradiography

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【作者】 纪云晶; 王贻嘉; 栗建林; 姚山麟; 关首任; 胡匡祜;

【Author】 Ji Yun-jing Wang Yi-jia Yao Shan-lin Guan Shou-renLi Jian-lin Hu Kuang-ku(Beijing Institute of Industrial (Institute of Biophysics, ChineseHygiene and Occupational Medicine) Academy of Sciences)

【机构】 北京市工业卫生职业病研究所; 中国科学院生物物理所; 中国科学院生物物理所;

【摘要】 本文介绍用整体、显微、层析放射自显影技术观察14C-ASU在小白鼠体内吸收分布与排出,揭示14C-ASU在小鼠体内半小时吸收达到高峰并全身分布。14C-ASU化合物在体内仍以原来形式存在,不直接参与体内代谢作用,说明它在体内累积中毒的可能性小。

【Abstract】 This paper reports the observations of the distribution and metabolism of 14C-ASU in animal studied by the techniques of whole body, microscopic and chromatographic analysis autoradiography. It was found that 14C-ASU was absorbed and distributed over the whole body, reaching a peak within half an hour. Since 14C-ASU compound in the body remains in its original form and doesn’t take part in the metabolism directly, the possibility of its cumulative poisoning in the body is rather small.

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