【摘要】 <正> 最近,我们观察到将P物质(以下简称SP)注入到家兔的中缝核群,可以显著地提高动物尾部透入钾离子引起尾部收缩及局部轻度挣扎反应的耐痛阈。1977年MalicK等人报导将SP注入大鼠中脑导水管周围的中缝背核,有镇痛作用。这些资料提示SP可能改变中枢神经系统某些结构的活动而起镇痛作用。国内不少工作认为尾核是一个抗痛结构,尾核神经元活动的调制与抗痛有关。更多还原

【Abstract】 The chronic microelectrode techniqes were carried out on 21 rabbits and 52 units in the head of caudate nucleus were recorded. Synthetic subsance p (SSP) were infused into the raphe nuclei of midbrain. The results showed that in 36 Units tested with SSP (10μg/5μl) , 27 (75%) were modulated——18 (50%) were excited and 9 (25%) were inhibited, The rate of spontaneous discharge was altered markedly and was prolonged over 10-30 min. The most neurons of caudate nucleus excitated by SSP were mid frequency units. They were distributed in the superficial area in the head of the caudate nucleus. From the results of the present experiment, it is concluded that the analgesic effect of SSP is possibly mediated by the raphe nuclei and SSP might be one of the analgesic factors in CNS, which modulates the activity of neuron in the head of caudate nucleus by way of midbrain raphe nuclei .更多还原