【摘要】 本文由正-二十四烷酸与五氯化磷反应,得到的二十四烷酰氯在氯仿中和三乙胺存在下与1-吗啉-1-环己烯反应所得中间体,经酸性水解,碱性开环和酸化,得到7-氧代-三十烷酸,而据文献报导[7],正-二十四烷酞氯与1-吗啉-1-环己烯反应结果,得到的仍然是原料二十四烷酸。 作者采用上述方法合成了五种新的7-氧代烷酸R—C—（CH²）⁵—COOH(R=n-C₁₄H₂₉,n-C₁₆H₃₃,n-C₁₈H₃₇,n-C₂₁H₄₃和n-C₂₃H₄₇)。 所制得的7-氧代三十烷酸经黄鸣龙改良的开息纳尔-武尔夫还原,再经四氢锂铝还原,即得三十烷醇。更多还原

【Abstract】 Five new 7-oxo-alkanoic acids,R-CO-(CH2)6-COOH (Where R=CH3-(CH2)13,CH3(CH2)15,CH3(CH2)17,CH3(CH2)20 and CH3(CH2)32),have been prepared by the reaction of carboxylic chlorides with 1-morpholino-1-cyclohexene.The acids thus formed were reduced twice by first Huang-Minion modification of the Wolff-Kishner method and then lithium aluminum hydride,giving the corresponding higher primary alkanols.We studied the necessary conditions of the reaction of long chain acyl chlorides with 1-morpholino-l-cyclohexene in the presence of triethyl amine and successfully prepared the 7-oxo-alkanoic acids.更多还原