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人参对大白鼠肾上腺细胞内环式腺苷酸(cAMP)含量的影响

INFLUENCE OF PANAX GINSENG ON THE ADRENAL INTRACELLULAR CYCLIC ADENOSINE MONOPHOSPHATE (cAMP) LEVEL IN RATS

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【摘要】 <正> 既往我们对人参的研究,已初步证明人参对垂体——肾上腺皮质系统有明显的抗应激作用。即增加非特异性刺激(如高温、低温和低气压缺氧等)的耐受能力。但其对垂体——肾上腺皮质系统作用的环节尚非清楚。近年由于分子生物学的发展,人们了解到垂体释放促肾上腺皮质激素,随血液循环,在肾上腺皮质细胞膜上与膜受体结合,从而激活肾上

【Abstract】 These experiments indicate that crude preparations of Panax ginseng increase a highly significant adrenal intracellular level of cyclic AMP?when injected intraperitoneally into the rats.In rats which have received hypophysectomy, adrenal intracellular level of cyclic AMP does not increases if Panax ginseng is given while if ACTH is given it rapidly increases 27 times higher than that in the rats without hypophysectomy.In addition, when using phenobarb ital sodium and dexamethasone to block hypothalamic release factor, Panax ginseng can elevate cyclic AMP levels in the rat adrenals.It appears that it is by means of hypophysis that one of the mechanisms of panax ginseng works.

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