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短期注射环一磷腺苷所引起的小鼠腹水瘤U14细胞动力学变化

CELL KINETIC CHANGE OF MOUSE ASCITES TUMOR U14 INDUCED BY SHORT TERM INJECTIONS OF CAMP

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【摘要】 <正> 许多研究报告指出,环一磷腺苷(以下简称cAMP)在控制细胞生长上有重要作用。它能使许多细胞株,特别是转化细胞和瘤细胞株在对数期生长减慢,,它也能抑制动物某些移植瘤的生长。一个细胞群体生长得快或慢,除了其中的生长分数和细胞丧失等因素外,与细胞周期的长短有很大关系,因此很多学者都探讨过cAMP对细胞周期的影响。

【Abstract】 Two injections of cAMP slightly inhibited the growth of mouse ascites tumor U14 and its mitotic index. Labeling index of both experimental and control groups was similar. Since the number of G2 cells increased and tG2 was Longer than normal, our study has shown that U14 cells were blocked at G2 phase by two injections of cAMP.

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