【摘要】 <正> 关于垂体-肾上腺皮质系统和针刺镇痛的关系已有一些报道。脑内埋藏皮质激素后,在大白鼠肾上腺皮质发生萎缩的同时,针刺镇痛效应明显下降(中山大学生物系,1977)。给大白鼠摘除垂体后,针刺镇痛效应也明显减弱;但摘除垂体后补给促肾上腺皮质激素(ACTH)的动物,其针刺镇痛效应并不减弱(苏州医学院,1976)。中国科学院动物研究所对这一问题进行了多方面的动物实验和临床观察,认为糖类皮质激素并不参与针刺镇痛作用(1978)。更多还原

【Abstract】 There is disagreement in experimental data concerning the relationship between acupuncture analgesia and pituitary-adrenoeortical system.In our previous work it has been shown that in hypophysectomized rate the analgesic effect of electro-needling "Zu-sanli" was reduced,hut in ACTH-maintained hypophysectomized rats the analgesic effect of electro-needling did not become reduced.In the present study We used competitive protein binding analysis method to measure plasma corticosterone level of rats and further studied the effect of hypophysectomy on lip-acupuncture analgesia.The adult male rats were used in this experiment.The pain threshold was measured by electrical stimulation of the rat tail with 57-9D type algesimeter.Electro-needling was performed with "Renzhong" and "Chengjiang".The blood sample from tail veins was collected and used to measure plasma corticosterone.The operation of hypophysectomy was transauricular.In 1-2 weeks after hypophysectomy,no plasma corticosterone could be detected by the employed method;at this time the analgesic effect of acupuncture was greatly decreased.In comparison with the control and sham operation groups there was a significant difference (P<0.05).It seems that hypophysectomy night reduce the analgesic effect of lip-acupuncture.When hypophysectomized rats were given ACTH intra-peritoneally (15 units/Kg),the basal pain threshold was reduced markedly,and the recovery of acupuncture analgesia ensued,but the plasma corticosterone level remained minimum (2.04±0.50μg/100 ml).However,if corticosterone was given intraperitoneally (300μg/100g),the basal pain threshold of hypophyseetomized rats did not change significantly and the analgesic effect of acupuncture remained unrecovered,white the plasma corticosterone rose to a rather high level (23.06±2.08μg/l00 ml).It is,therefore,demonstrated that there is no parallel relationship between acupuncture analgesia and the plasma corticosterone level.The results suggest that the cause of decreased acupuncture analgesia in hypophysectomized rats was,probably,due to the defect of central actions of pituitary ACTH rather than the deficiency of plasma eorticosterone.In addition,the lip-acupuncture might be able to evoke stress response,which,in turn,caused the plasma corticosterone level elevated.更多还原