【摘要】 在各有关农场和种植单位协助下,采集了我国产龙舌兰属5个种17个植物样品,证实其中皆含有甾族药物的原料海柯皂甙元。以番麻(Agave americana L.)、剑麻(A.sisalana Perr.)和无剌番麻(番麻的一个变种)中的含量高。为了进一步探讨它们作为生产甾族原料的可能性和生产上合理应用,选择了3种有代表性的样品,对其总甾族皂甙元进行了分离和鉴定。从福建生长的亚洲马盖麻(A.canatala Robb.当地称狭叶龙舌兰麻)中分离出β-谷甾醇(β-sitost-erol)、新替告皂甙元(Neotigogenin)、海柯皂甙元(Hecogenin)、芰脱皂甙元(Gitogenin)、绿莲皂甙元(Chlorogenin)和曼诺皂甙元(Manogenin)。从广东生长的假菠萝麻(A.angustifolia Haw当地称短叶龙舌兰麻)中分离出替告皂甙元(Tigogenin)、海柯皂甙元和绿莲皂甙元。从广东生长的无刺番麻中分离出替告皂甙元酮(Tigogenone)、β-谷甾醇、替告皂甙元、海柯皂甙元、9-去氢海柯皂甙元(9-Dehydrohecogenin)、绿莲皂甙元和海南皂甙元(Hainangenin)。本工作对利用国产龙舌兰麻生产海柯皂甙元或替告皂甙元提供了参考资料,在学术上也有一定意义。更多还原

【Abstract】 In order to search for more raw material for the industrial production of steroid drugs,with the help of several plantations,17 samples of 5 different species of Agave,namely A.americana L.,A.sisalana Perr.,A.cantala Roxb,A.angustifilia Haw,and a variety of A.americana gathered from Kwangtung,Kwangsi,and Fu- kien were examined.Hecogenin,the valuable raw material for the commercial pro- duction of steroid hormones,was found in all the samples tested.For the purpose of reasonable ultilization of the waste juice from the textile manufacturing,three species were selected for more detail study.β-sitosterol,neotigogenin,hecogenin, gitogenin,chlorogenin and manogenin were isolated from the leaves of A.cantala Roxb growing in Fukien;tigogenin,hecogenin,and chlorogenin from the leaves of A.angustifolia Haw growing in Kwangtung;tigogenone,β-sitosterol,tigogenin,heco- genin,9-dehydrohecogenin,shlorogenin and hainangenin from the leaves of a variety of A.americana growing in Kwangtung were isolated.This work is not only useful for commercial production of hecogenin and tigogenin,but also has some theoretical interest.更多还原