【摘要】 本文研究了家兔注射不同剂量胰岛素后不同时间的剂量反应关系。发现注射胰岛素后2～3小时,不同剂量引起的降血糖反应区别最明显、用2.5小时测定一次血糖值的兔法检定9批胰岛素(包括粉末和注射液)所获得的结果与小鼠惊厥法结果大部分是一致的。与美国药典XIX版比较,以2.5小时测一次血糖的方法精密度较大,正确性较高。通过不同设计的研究,提供了一个简便的胰岛素生物检定兔血糖法。更多还原

【Abstract】 This paper reports the dose-response relationship at different times after the rabbit was injected with various doses of insulin. At 2～3 hours, after injection of insulin we found that the differentiation of reduced blood-sugar reaction caused by various doses, was the most evident. The results obtained for nine batches of insulin (including powder and injection) by this method carried out at 2.5 hours to determine blood-sugar value, were mostly in conformity with those bythe mice convulsion method. This rabbit method Was found to be of higher precision and more accurate than, the USP ⅪⅩ rabbit method. A simple and convenient rabbit blood-sugar method for insulin assay was provided through the study of various designs.更多还原