【摘要】 伪石蒜硷是从石蒜科植物水仙及石蒜中提得的生物硷。其游离硷及盐酸盐在动物耐受剂量下,对大鼠W-256的生长有明显的抑制作用,抑制率在49～76％之间,统计学上差异非常显著。对小鼠肝癌、艾氏腹水癌皮下型、S-180的抑制作用不明显。已测得伪石蒜硷对大鼠一次腹腔注射的LD₅₀为110（92.4～131）mg/kg。对猫静脉滴注可致缓慢血压下降,滴注致死要求很大剂量（平均881mg/kg）。根据推算现在的病人试用剂量（～1mg/kg/日）是安全的。狗的亚急性毒性试验表明,此药可引起恶心、呕吐、厌食,但对骨髓无明显抑制作用。用药后曾见血中非蛋白氮值上升,考虑为肾前因素引起。病理解剖心、肝、脾、肺、肾、肠各脏器均未见明显病变。药物正开始进行Ⅰ期临床试用中。更多还原

【Abstract】 Pseudolycorine is an alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb. Both the free alkaloid and its hydrochloride showed marked inhibition on the growth of W-256 carcinosarcoma in rats under tolerable doses, but the inhibition on the growth of hepatoma, subcutaneous transplants of Ehrlich ascites cascinoma and S-180 in mice was not significant. The LD₅₀ of pseudolycorine injected intraperitoneally to rats was found to be 110（92.4～131）mg/kg. Intraveneous infusion of the drug caused slow lowering of the blood pressure in the cat, but the dose of the drug required to kill the cat is rather high （av. 881mg/kg）. The subacute toxicity tests in the dogs showed that pseudolycorine may induce nausea, vomiting and anorexia, but it did not inhibit the bone marrow significantly. Some increase of the nonprotein nitrogen value in the dogs after adminstration of the drug was observed, but this might be caused by prerenal factors. Autopsy of the dogs showed no significant pathological changes in the viscera, including the heart, liver, spleen, lung, kidney and intestine. Phase I clinical trial of the drug is now in progress.更多还原