【摘要】 联苯双酯系合成五味子丙素的一种中间产物。二苯乙烯系合成五味子丙素所用的一种化工原料,我们对这两种化合物与五味子和灵芝对小鼠肝脏的作用进行了比较,结果表明,对于四氯化碳、硫代乙酰胺引起的血清谷丙转氨酶(SGPT)升高,联苯双酯、五味子、灵芝及二苯乙烯均有降低作用。对强的松龙所致的SGPT升高,仅联苯双酯有降低作用,其余三种无效。对于四氯化碳和硫代乙酰胺引起的小鼠肝脏甘油三酯的蓄积,除联苯双酯无效外,五味子、灵芝及二苯乙烯均有明显降低作用。对强的松龙引起小鼠肝脏甘油三酯的蓄积,仅二苯乙烯能使其降低,而灵芝使其蓄积更多,联苯双酯和五味子则无明显影响,对DL-乙硫氨酸引起的脂肪肝,灵芝和二苯乙烯有明显预防作用,五味子无效,联苯双酯使蓄积更明显。此外,五味子和二苯乙烯能促进小鼠肝糖原的生成,联苯双酯对四氯化碳中毒小鼠有缩短戊巴比妥钠睡眠的作用。总之,上述四种药物对小鼠肝脏的作用,有的相似,有的不同。从临床治疗角度考虑,试用药物时,合并用药可能更好,这样各药可以取长补短。更多还原

【Abstract】 Ganoderma and Fructus Schizandrae were found to have SGPT-lowering action in hepatitis patients and in CCl₄-intoxicated animals. Trans-stilbene is a chemical reagent. Biphenyl-dimethyl-dicarboxylate is an intermediate in the process of synthesizing Schizandrin C, an active component isolated from Fructus Schizandrae. Both trans-stilbene and biphenyl-dimethyl-dicarboxylate were also shown to be capable of lowering the elevated SGPT levels in mice. In order to further understand the actions of the four agents mentioned above on liver, the following experiments were carried out in mice.The preparations of Ganoderma and Fructus schizandrae used were alcohol-ether extracts.In CCl₄ or thioacetamide intoxicated mice, prior oral administration of the four agents were shown to be effective for impeding the elevation of SGPT levels. All these agents, except biphenyl-dimethyl-dicarboxylate, were found to be able to decrease the accumulation of triglyceride in liver. The elevation of SGPT induced by the injection of prednisolone was impeded significantly by biphenyl-dimethyl-dicarboxylate but not by the other three agents. As to the prevention of the accumulation of triglyceride in liver, only trans-stilbene was shown to be active. On the contrary, Ganoderma potentiated the accumulation of triglyceride in liver caused by prednisolone.All the four agents were found to have no direct inhibitory action of the activity of SGPT in vitro.Ganoderma and trans-stilbene were shown to prevent the development of fatty liver induced by giving dl-ethionine, whereas Fructus Schizandrae was inactive. For promotion of glycogenesis in fasted mice, Frucutus Schizandrae and trans-stilbene were effective. In addition, Fructus Schizandrae was found to shorten pentobarbital sleeping time in both normal and CCl₄-intoxicated mice, while biphenyl-dimethyl-dicarboxylate only shortened pentobarbital sleeping time in CCl₄-intoxicated mice but not in normal mice.These resuhs indicate that the pharmacological actions of Ganoderma, Fructus Schizandrae, trans-stilbene and biphenyl-dimethyl-dicarboxylate on liver are different from each other, although they all have SGPT-lowering action in CCl₄ and thioacetamide intoxicated mice.更多还原