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肿瘤的化学治疗——ⅩⅩⅩⅤ.若干植物生长控制剂的衍生物的合成及其抗肿瘤作用
TUMOUR CHEMOTHERAPY ⅩⅩⅩⅤ. Syntheses of derivatives of some plant growth regulators and their antitumour activity
【摘要】 鉴于作者过去曾报道植物生长控制剂与肿瘤细胞的关系及其一些特点,合成了一系列带有强烈生物作用化合物为载体的植物生长控制剂衍生物(Ⅺa-d,Ⅻa-f,Ⅻa-e)和羟基萘乙酸(ⅩⅣa-l)羟基萘氧乙酸(ⅩⅤa-g)等化合物。药理试验结果Ⅺa,Ⅻs,b,Ⅻa,ⅩⅣf,h对肉瘤180或肉瘤37均有明显的抑制作用,其中化合物Ⅺa(代号AT-236)已作了初步临床试验,深入工作尚在进行中。
【Abstract】 In continuation of our investigations of syntheses of derivatives of plant growth regulators for screening antitumour agents we report in this article the syntheses of the following series of compound, namely, the derivatives of naphthalene acetic acids and naphthalene glycolic acids both with a hydroxy substituent in the various positions of the aromatic rings, and the derivatives of some well known plant growth regulators carried by biologically active compound. The synthetic compounds have all been subjected to experimental antitumour tests. Preliminary results showed that Ⅺa. Ⅻa,b, ⅫⅠa and ⅪⅤf,h to be much stronger inhibitors against Sarcoma 180 or Sarcoma 37. Compound Ⅺa (designated as AT-236) has been submitted to clinical trials. Further research works are in progress.
- 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1979年05期
- 【被引频次】3
- 【下载频次】20