【摘要】 <正> 棉酚为棉子及棉根皮中的生物学活性物质,1972年初步试用于男子节育时即已表明,本品在一定剂量下可使精液中精子失活,然后消失;亦表明,此作用是可逆的,停药后不久即恢复,而且对性功能影响不大。棉酚也具有某些抗肿瘤活性,1973年以来国内即试用于治疗肿瘤,但治程中少数患者发生低血钾性肌无力或低血钾性心功能紊乱。此后,低更多还原

【Abstract】 Since 1972 gossypol, a biologically active constituent of cotton seed and cotton root bark, was shown to have a potent spermatocidal effect in man. Glinical trials pointed out that occasional cases of hypokalemia and hypokalemic paralysis might happen in the course of gossypol administration. Little was known concerning the intrinsic relationship between gossypol and such hypokalemias.The authors indicated that in isolated rabbit heart brief perfusion with Lock’s solution containing gossypyl 2 mg/l could induce a significant loss of the potassium content of the left ventricular myocardium, together with a drastic depression of its contractility. These actions were reversed when Mg²⁺ （2～4 me/l） had been added beforehand to the perfusion solution. It is suggested that the potassium-depleting （and negative inotropic） effect of gossypol on the isolated heart might be the consequence of its possihle inhibitory action on Na-K-ATPase （and/or other Mg-dependent enzyme systems involved in energy metabolism）, thus interfering in the active potassium transport.更多还原