【摘要】 <正> 巴马亭(Palmatine)是一种生物碱,其化学结构与延胡索乙素及小蘖碱相似.作者在研究巴马亭等药物对大鼠ACTH分泌活动的影响时,观察到大鼠于皮下注射巴马亭约半小时后,动物的嘴鼻部及四肢出现明显的浮肿.为了解巴马亭的致浮肿作用及此作用的性质,我们作了下列的研究.结果与讨论所用动物为体重100-150克的雄性大鼠.用微分卡尺量大鼠的一侧后爪的厚度.以给药前与给药后后爪厚度相差的毫米数,作为判定浮肿形成的程度的指标.(一)大鼠对注射巴马亭的类过敏反应更多还原

【Abstract】 Palmatine given subcutaneously at the dosage of 50 mg/kg to male rats weighing 100-150 grams produced hyperaemia and oedema of the paws within half an hour. Local injection of 25 micrograms of palmatine in 0.1 ml to the hind paw elicited a similar response. Pretreatment of the rat with intraperitoneal injection of diphenhydramine (75 mg/ kg) or chlorpromazine (5 mg/kg) significantly inhibited the oedema of the hind paws induced by subcutaneous injection of palmatine. Diphenhydramine (75 mg/kg) and Dibenamine (15 mg/kg) given concomitantly, or chlorpromazine (5 mg/kg) given alone, prevented significantly the formation of oedema of the hind paws elicited by locally in- jected palmatine. Following subcutaneous injection of palmatine, the histamine content of the peritoneal fluid was found to be higher than that of the control. Therefore, the anaphylactoid reaction of the rat to the injection of palmatine is the result of histamine and probably 5-hydroxytryptamine release.更多还原