【摘要】 <正> “扭体反应”是给小白鼠或大白鼠腹腔注射某些药物所引起的一种间歇发作的运动反应,表现为腹部收缩、腹前壁紧贴笼底、臀部歪扭和躯干后肢伸展,呈一种特殊姿势。国外一般称为“Writhing”,也有称为“Stretching”、“Cramping”、或“Squirming”。这种反应的发生机制和它在药理学上的意义迄未肯定。由于镇痛药可对机这一反应,曾建议用作筛选镇痛药的方法。本实验目的是研究“扭体反应”的发生机制,从而探讨其在药理学上可能具有的意义。更多还原

【Abstract】 The "writhing" response in the mouse is a characteristic body movement and postural change caused by certain drugs following their intraperitoneal administrations. The purpose of this experiment was to study the mechanism of "writhing" in the mouse. The following results were obtained: 1.Various irritants tested, such as alkali, acids, salts of heavy metals and others, all caused "writhing", but non-irritants were ineffective. 2. The measures of reducing irritation of drugs could abolish the activity of drugs to cause "writhing". 3. "Writhing" was produced by mechanical irritation to the tissues in the centre of the abdominal cavity. 4. When the chemical or the mechanical irritation only acted on the serosa of the intestine, "writhing" was also caused. 5. "Writhing" response was inhibited selectively by a prior administration of analgesics. According to the results obtained, it is considered that "writhing" is a visceralsomatic reflex caused by the irritation of drugs to thc serosa of the intestine or the mesentery.更多还原