【摘要】 复方“二仙合剂”由仙茅、淫羊藿、巴戟天、黃蘗、知母及当归組成,所用药液均为水煎剂。正常狗每日灌胃給二仙合剂18克/公斤,連服20天,无毒性反应。增加剂量3—4倍,則有嘔吐泄泻,可能由于药液容量过大,影响消化道的机能。麻醉猫十二指腸注射二仙合剂6克/公斤,30分钟后血压开始下降,2小时后平均降低原水平的30％。慢性腎型高血压狗斗只,每日灌胃給二仙合剂2次,第1—10天剂量为9克/公斤/天,第11—20天剂量为18克/公斤/天,停药10天。舒张压“30天平均降压值”平均为10毫米汞柱(8％),“最低5天降压值”平均为16毫米汞柱(12％)。4狗中3狗呈現疗效(舒张压下降11毫米汞柱或以上),其中2狗重复一次試驗依然降压有效。麻醉狗腹腔注射二仙合剂6克/公斤,在急性降压时有心脏指数的减少,而外周血管的扩张并不明显。单味药的比較試驗証明黃蘗和淫羊藿为二仙合剂降压作用的主要有效成分,而仙茅几无降压效能。高血压狗8只,每天服二仙合剂或分煎合剂,变异数分析証明分煎合剂的降压效果不亚于二仙合剂。高血压狗灌胃試驗二仙減巴合剂,降压效果并不較二仙合剂为弱,所以我們建議复方二仙合剂中可減省巴戟天。更多还原

【Abstract】 The "Compound Mixture of Two Fairies" has been used clinically for treatment of hypertension. It is composed of Curculigo ensifolio, Epimedium, sp., Morinda officinalis, Phellodendron chinense, Anemarrhena asphodeloides, and Angelica sinensis. In normal dogs, intragastric administrations of 6g (crude drugs) per kg t.i.d, for 20 days produced no toxic reactions: If the dosage was increased 3—4 times, emesis and diarrhea occurred, probably due to alimentary disorder from the bulk of the decoction. When the Compound Mixture was introduced 6. g/kg into the lumen of duodenum in anesthetized cats, the blood pressure began to descend at 30 minutes, and lowered an average of 30％ below the original level in 2 hours. Four Goldblatt renal hypertensive dogs were given the Compound Mixture by stomach tube. The dose for the first 10 days Was 9 g/kg/day, and doubled for the next, 10 days. The post-medication observation period was another 10 days. Blood pressure was measured daily by auscultation on the carotid loop. The average reduction of the diastolic pressure in the space of 30 days was 10 mm Hg (8％), and that for the lowest 5 days running was 16 mm Hg (12％). A therapeutic action (a reduction of at least 11 mm Hg diastolic) was demonstrated in 3 dogs. Among them 2 dogs received a second course of treatment which appeared to be equally efficacious. Intraperitoneal injections of the Compound Mixture 6 g/kg to anesthetized dogs resulted in a decrease of cardiac output during the hypotension, while the dilatation of peripheral vessels was insignificant. Comparative experiments on the 6 ingredients revealed that the hypotensive action of "Compound Mixture of Two Fairies" could be primarily attributed to Phellodendron chinense and Epimedium sp., whereas Curculigo ensifolio alone had little effect. Eight hypertensive dogs were fed daily the Compound Mixture or a mixture of 6 decoctions of the components. Analysis of variance disclosed that the hypotensive potency of the former was no better than the latter. Hypertensive dogs were fed the Compound Mixture which was devoid of Morinda officinalis, and the therapeutic potency was shown to be no less than that of "Compound Mixture of Two Fairies". Hence, we deem that Morinda officinalis is dispensable.更多还原