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酒石酸锑钾溶液浓度与疗效的关系(血吸虫病实验治疗研究之十一)

STUDIES ON THE EXPERIMENTAL THERAPY OF SCHISTOSOMIASIS JAPONICA.Ⅺ.THE CORRELATION BETWEEN CONCENTRATION OF SOLUTION AND CURATIVE EFFECT OF POTASSIUM ANTIMONYL TARTRATE.

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【作者】 乐文菊; 杨嘉煜; 商韵征;

【Author】 LE WEN-JU YANG JIA-YU SHANG YUN-CHENG (Institute of Parasite Diseases,Chinese Academy of Medical Sciences,Shanghai)

【机构】 中国医学科学院寄生虫病研究所; 中国医学科学院寄生虫病研究所 上海; 上海;

【摘要】 <正> 目前在临床上应用酒石酸锑钾治疗日本血吸虫病时,一般皆用1%浓度的注射液。1956年日本医学代表团来华访问时,曾提及在日本应用锑剂治疗血吸虫病时,注射液浓度仅为0.3%,注射量相应地增加,疗效很好,为了明嘹锑剂浓度与疗效的关系,乃用酒石酸锑钾不同浓度的注射液,进行家兔动物实验治疗,以比较其疗效。

【Abstract】 In order to ascertain the correlation between schistosomicidal effect and the concentration of solution of potassium antimonyl tartrate,investigation was made in experimentally infected rabbits treated intravenously with the same dosage of potassium antimonyl tartrate in 3 different concentrations.The average number of worms recovered from groups of animals receiving 0.5%,1% and 2% solutions was 26.9,30.3 and 41.1 respectively while that from untreated animals was 104.0.It seems that the curative effect of potassium antimonyl tartrate is inversely related to the concentration of solution used.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1959年01期
  • 【被引频次】1
  • 【下载频次】12
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