【摘要】 <正> 广寄生系桑寄生属植物,按国产桑寄生因产地不同而有三种,产于珠江流域者称广寄生,产于长江流域者称杜寄生,产于华北及东北者称北寄生。我国自古即以桑寄生供药用,神农本草经将其列入上品,大明本草谓能“助筋骨,益血脉”。近代学者用做强壮剂、消肿……及治高血压,血管硬化性四肢麻木……。关于广寄生之化学研究,最近本文作者之一(曾广方)自广寄生(Loranthus paracticusL. C. Merr.)中分离出两种结晶,其中之一为—黄酮类苷,暂称为广寄生苷,水解所得之更多还原

【Abstract】 The Flovonearabinoside,isolated from Kwang-Chi-sheng,has a transient depressor effect in anesthetized dogs. On repeated injections,tachyphylaxis was noted.From our experiments the glycoside showed a powerful diuretic action.The urine volume was increased when intravenously injected at doses of 0.5—2mg/kg on 21 anesthetized dogs. The substance was given orally and subcutaneously to 232 unancsthetized rats at a dose of 34 mg/kg,the urine volume increased 16 and 23％ respectively,and 27％ increased was recorded at a dose of 100 mg/kg intraperitonealy as compared with the controls.The diuretic action of the arabinoside was compared with aminophylline,the potency of the former was found to be about 4/5 to 3/5 of the latter at same doses on rats. When the drug was injected intraperitonealy,the LD₅₀for mice was found to be 1173mg/kg,which is about one fourth that of aminophylline,In case of intoxication,clonic-tonic convulsions occurred after 10—20 minutes of the injection,and death was due to respiratory failure.更多还原