【摘要】 <正> 关于离子交换作用在生物鹼类的提取和分离上,曾有过许多报告。例如Apple-zweig 应用离子交换剂自金鸡纳树皮的酸浸出液中直接分离出生物鹼,而建议用于工业生产上;Kingsbury等利用氢离子型交换剂以回收烟厂中因干操烟叶时挥发损失的烟鹼;Grant和Hilty二氏则应用阴离子交换剂分离了吗啡和可待因,并自混合物中,测定了它们的含量;著者等亦应用氢离子型的磺化煤测定了常山中生物鹼的含更多还原

【Abstract】 (1) The method of the separation of hydrochlorides of ephedrine and pseu- doephedrine by means of ion exchanger with the liquid chromatographic technique is described. (2) The method of isolation of ephedrine hydrochloride from the ephedra herb using the ion exchange chromatography is also presented. In this method, forty grams of cation exchange resin——sulfonated coal, is converted into H~+ form in a glass column 3×33 cm, and after removal of the excess acid with distilled water, an acidic extraction (0.5%HCI) of ephedra herb (500 gms) is passed through the column at the rate of 40-50 drops per minute. The resin is then washed with distilled water and small amount of alcohol until the washings become almost colorless and then ephedrine is displaced by the addition of 4N hydrochloric acid. The first 1000 ml acidic eluent is collected which is concentrated in dimin- ished pressure, from the residue obtained, after recrystallization, 1.58 gm of ephe- drine hydrochloride qualified for the requirements of Chinese Pharmacopoeia is ob- tained with about 70% yield.更多还原