【摘要】 <正> 汉防己(Stephania tetrandra S. Moore)在中医临床上,主治风湿性疼痛,其所含汉防己甲素及汉防己乙素之镇痛作用,已在我们实验室中,采用电刺激小白鼠尾巴法,予以证实。同时我们采用了大白鼠甲醛性关节炎的方法,试验了汉防已甲素及乙素之消炎作用,结果发现它们均具有不同程度的消炎作用.风湿症系一过敏性疾病,据文献报告,许多治疗风湿病的药物,如水杨酸钠、阿斯匹林、匹拉米董、安替匹林及日产汉防已鹼(Sinomenine)均具有抗过敏性休克的作用,但更多还原

【Abstract】 Tetrandrine and demethyl-tetrandrine are alkaloids isolated from the Chinese drug Han Fang Chi (汉防已), the root of Stephania tetrandra S. Moore. Han Fang Chi is used in the Chinese medicine as an antirheumatic and analgesic. According to another experiment conducted in our department with the Grewal’s method, the two alkaloids seem to have only slight analgesic action. Presumably, the drug might be only antiphlogistic, and the analgesia a secondary effect. In the present - paper, we are reporting experiments undertaken to determine whether the two alkaloids be antiphlogistic and possess anti-anaphlactic and anti-histamine shock actions, as many antipyretics do. At the same time, the vitamin C content in the adrenal gland of the experimental animals is also estimated. The results of our experiments are summarized as follows:- 1. Tetrandrine and demethyl-tetrandrine possess definite antiphlogistic action on the formaldehyde-arthritis of the rats. 2. Tetrandrine shows a slight protective action against anaphylactic shock induced by injecting egg albumen to rabbits, but no action against histamine shock in guinea pigs. 3. A significant reduction in vitamin C content of the rat’s adrenal glands was observed after tetrandrine (1.5 mg./100 gms., intraperitoneally), indicating a stimulating action on the pituitary-adrenal system, causing hyperfunction of the adrenal cortex, similar to some antipyretics. 4. It seems, therefore, that the two alkaloids studied belong to the so called antipyretic analgetics.更多还原