【摘要】 本实验选择了胰凝乳蛋白酶与胰蛋白酶,它们同属水解酶,能够内切蛋白质与肽类底物的某些键位。26只刚成年的雄性大鼠分作三组:生理盐水/不巩固组（NS/NC）、胰蛋白酶/不巩固组（T/NC）与胰凝乳蛋白酶/不巩固组（CT/NC）。 实验结果表明,双侧海马内注射（AP₂L₂H₄与AP₄L₃H₅）胰凝乳蛋白酶与胰蛋白酶后,对暗箱廻避（DBA）模式记忆有不同的影响。胰蛋白酶注射后,该记忆保持明显降低,而胰凝乳蛋白酶注射后仍可巩固。所用的实验剂量大致为半致死剂量的三分之一。更多还原

【Abstract】 Two instrumental enzymes, Chymotrypsin （CT） and Trypsin （T）, both are pro-teolytic enzymes capable of destroying some bonds of proteins and peptides, were usedin this experiment. A total of 26 young adu1t male albino rats served as the threenon-consolidation groups （NC） of DBA memory: normal saline solution （NS/NC）,Trypsin （T/NC） and Chymotrypsin （CT/NC）. After bilateral injection of CT and T into the Hippocampus （iH: AP₂L₂H₄ andAP₄L₃H₅）, different effects were observed on the conditioned reflex of DBA memorymodel (CR_DBA). 72 hours after iH. T, retention of CR_DBA clearly decreased, but afteriH. CT, memory remains consolidated. Differences in successive number of CR_DBA(SN_CR) and rate of CR_DBA （CR%） were statistically significant. The experimentaldoses of iH. T and CT approximately equal 1/3 of their LD₅₀.更多还原