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中药的抗流感病毒作用

THE INHIBITORY ACTIVITY OF CHINESE MEDICINAL PLANTS ON INFLUENZA VIRUS

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【作者】 刘国声蒋景仪陈鸿珊陈兆华

【Author】 LIU KUO-SHENG;CHIANG CHING-YI;CHEN HUAN-SHAN;CHEN CHAO-HUA Institute of Pharmaceutics Chinese Academy of Medical Science Insitute of Antibiotics, Chinese Academy of Medical Sciences

【机构】 药物研究所中国医学科学院抗菌素研究所

【摘要】 <正> 流行性感冒的预防和治疗,至今尚无广泛应用的有效药物。韩大卫和叶景华等试用中药复方在流行期间预防和治疗流感病人,有降低发病率和治疗的效果。实验室证实有抗病毒作用的中药有王善源、王守良、朱锡华和湖北省防疫站等的报告,他们发现黄连、槟榔、常山和银翘散等有抑制流感病毒的作用。苏联学者Дреиэнн,Соко-

【Abstract】 More than 320 kinds of aqueous decoctions o Chinese medicinal plants were screened for theirin vitro and in vivo antiviral activity against influenza virus in chick embryos. Out of 240 single-plant decoctions, 32 showed in vitro inhibition, and among these sliced areca nut and 14 othersshowed rather strong activity. The minimal inhibitory concentration of the sliced areca nut was about80 mcg/ml, being approximately equal to that of purified tannic acid. Most of the active plantscontained tannin. Out of 80 kinds of combined decoctions, 4 showed in vitro inhibitory activity.One of these four is a decoction of Louicera and Forsythia. This decoction was commonly used inthe clinics under the name "Yinchiaosan", and was reported by clinicians to have some beneficialeffect on influenza. Only few of the plant decoctions active in vitro showed in vivo inhibitory activity. In order to get repeatable results in the screening, the infective dose of virus, the pH of the decoc-tions and the duration and temperature of the contact between the drug and the virus must berigidly controlled.

  • 【文献出处】 微生物学报 ,Acta Microbiologica Sinica , 编辑部邮箱 ,1960年02期
  • 【被引频次】11
  • 【下载频次】173
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