【摘要】 本文主要讨论了大、小白鼠的致畸敏感期。根据我们的实验结果认为:大白鼠胚胎对Bis-HM-A-TDA 的反应以妊娠的第9、10和11天者最为敏感;在畸形发生上则以妊娠的第10、11和12天的胚胎最为敏感。小白鼠的胚胎以妊娠的第7、8和9天者反应最为敏感;在畸形发生上又以妊娠第9、10和11天的胚胎为敏感,尤其妊娠第9天的胚胎反应更为强烈。随着胚胎发育时间的延长,胚胎对于致畸因素的抵抗力逐渐提高。更多还原

【Abstract】 The present experiment was conducted with sexually mature,virgin female rats and mice.The body weight of the female rats was 180-280g and that of the male was 250—350g;the body weight of the female micewas 25-40g and that of the male micewas 25—35g.The females and maleswere mated over-night,♀∶♂ ratio ofthe rats was 3∶1;that of mice was2∶1.The female rats were conside-red day-o of gestation when the spermswere found in the vagina.If thecopulation plug was found in the fe-male mice,then that day was assig-ned day-o of gestation.Then the preg-nant rats and mice were divided intogroups:the rats,into ten test-groups(6—15days) and one control;the mice,into five test-groups (7—11 days) andone control.The pregnant female rats of eachgroup were given single p.o.with thetest—chemical from day-6 to day-15of gestation daily respectively;the pre-gnant mice received single p.o.of thesame drug from day-7 to day-11 of ges-tation daily respectively.The dosagewas 7.5 mg/kg for the pregnant ratsand 150 mg/kg for the pregnant mice.All pregnant rats were killed on day-20 of gestation so as to count the number of corpora lutea,implantation,resorption sites and live fetuses.After giving birth the female mice were kil-led on the day of parturition.Thenumber of implantation,resorptionsites and living fetuses were also coun-ted.The living fetuses of the rats andmice were removed,weighted,inspec-ted for gross abnormalities and sexes;but only the internal and skeletal mal-formations of the rats were examined.Under present experimental con-ditions,determination of the rats ter-atogenic susceptibility in different deve-lopmental periods showed that embryoswere most susceptible on day-9,day-10and day-11 of gestation,whereas themice were most susceptible on day-7,day-8,and day-9 of gestation.The rats were most susceptible toteratogenesis on day-10,day-11,andday-12;whereas the mice,on day-9,day-10,and day-11.The abnormalities of the rats,ex-cept exencephaly and absence of ma-xilla,were the same as teratogenesis ofDI-KU-SHUANG Bis-A-TDA);however,all the abnormalities of the mice consist with teratogenesis of DI-KUSHUANG (Bis-A-TDA).更多还原