【摘要】 杆菌肽50微克/0.05毫升脑室内注射明显延长家兔手针双侧足三里引起的镇痛效应,在停针后30—40分钟痛阈仍维持很高的水平。测定这时脑内各区的脑啡肽含量,发现杆菌肽手针组纹状体及下丘脑含量显著高于生理盐水手针组及杆菌肽对照组。纹状体尤其明显,比杆菌肽组高1—2倍。停针后30分钟生理盐水手针组在纹状体尚有脑啡肽增高的痕迹,但近不及杆菌肽手针组。在杆菌肽延长针刺镇痛期间,纳洛酮可以明显翻转这种镇痛效应,说明杆菌肽的增强作用可能通过内源性吗啡样物质而实现。更多还原

【Abstract】 Intraventricular injection of bacitracin 50 μg/50μl greatly prolonged theanalgesic effect of manual needling of Tsu-San-Li points in rabbits.Pain thresholdremained high 30-40 minutes after withdrawing the needles,whereas in the salineacupuncture group analgesic effect could no longer be demonstrated at this time.Estimation of two enekphalin levels in various brain regions revealed that thecontents in striatum and hypothalamus were much higher than those in the salineacupuncture and bacitracin control groups.This was especially conspicuous instriatum,where the enkephalin contents of bacitracin acupuncture group were2-3 times higher than those of the bacitracin control group.Thirty minutes afterthe cessation of needling,a trace of enkephalin increase in striatum was still foundin the saline acupuncture group.Naloxone effectively antagonized the analgesiceffect during the bacitracin prolongation period,indicating the enhancement byintraventricular bacitracin was due to the preservation of released endogenousmorphine-like substances.更多还原