【摘要】 本文对正常、冠心病及心肌梗塞病人共247例的血清进行了琼脂糖电泳和胆固醇、甘油三酯及β脂蛋白的含量测定。主要根据βLP 电泳图象的类型,必要时参考血清脂质含量将247例被检人员分为Ⅱ-1、Ⅱ₂、Ⅱ₃、Ⅱ₄、Ⅲ、Ⅳ、Ⅴ七种不同的类型。按其在每种类型中分布多少排列次序如下:Ⅱ₄>Ⅱ₃>Ⅳ>Ⅱ-1>Ⅱ₂>Ⅲ>Ⅴ。以Ⅱ₄最多,88例,Ⅴ型最少,仅2例。247例中118例有高脂蛋白血症。他们在各型中的分布情况亦以Ⅱ₄型为最多,Ⅴ型最少。排列次序与上述情况类似;为Ⅱ₄>Ⅳ>Ⅱ₃>Ⅱ₂>Ⅱ-1>Ⅱ>Ⅴ型。118例高脂蛋白血症者中67例有冠心病,34例有高血压,20人有 MI。冠心病的分 布以Ⅱ₄,Ⅳ及Ⅱ₃型较多,Ⅱ₁型中最少,Ⅲ、Ⅴ型中无,但以本型计则发病率以Ⅱ₂、Ⅱ₁和Ⅱ₃较多,Ⅱ₄及Ⅳ型中较少,MI 多集中于Ⅳ、Ⅱ₄及Ⅱ₃型中。说明Ⅱ及Ⅳ型与冠心病的关系较为密切。此外,还观察了104例冠心病和42例高血压在各型中的分布,发现二者均较集中地分布于Ⅱ₄Ⅳ及Ⅱ₃型中。比较了它们在高 Tg、高 Ch 及高脂蛋白血症中的发生率。发现冠心病和高血压与高脂蛋白血症的关系比高 Ch 及高 Tg 血症更为密切。以上结果均说明Ⅱ、Ⅳ型与冠心病、高血压有密切关系,因此对该二型高脂蛋白血症的早期发现和治疗对冠心病的防治看重要意义?更多还原

【Abstract】 Quantitative determinations of serum β-lipoprotein,cholesterol and trigly-ceride and agarose-gel electrophoresis have been made on normal subjects andpatients with coronary heart disease（CHD）,myocardium infarction（MI）andhypertension,totalling 247 cases.According mainly to the data of agarose elec-trophoretograms,the 247 subjects could be classified into seven different types,namely,types Ⅱ₁,Ⅱ₂,Ⅱ₃,Ⅱ₄,Ⅲ,Ⅳ,and Ⅴ.The distribution of these 247 casesin each type was different,being the highest in type Ⅱ（88 cases）and the lowestin type Ⅴ（2 cases）.The order of the overall distribution was as follows:TypesⅡ₄,>Ⅱ₃>Ⅳ>Ⅱ₁vⅡ₂>Ⅲ>Ⅴ.Among the 247 subjects examined,there were 118 cases of hyper-β-lipopro-teinemia.Their distribution in each type was similar to the above results,beingalso highest in type Ⅱ₄（44 cases）,and lowest in type Ⅴ（2 cases）.The overalldistribution was that Ⅱ4>Ⅳ>Ⅱ₃>Ⅱ₁>Ⅲ>Ⅲ>Ⅴ.Amongthe 118 cases of hyper-β-lipoproteinemia studied,there were 67 casesof CHD,34 cases of hypertension and 20 cases of MI.The distribution of CHDin different phenotypes of hyper-β-lipoproteinemia of types Ⅱ₄,Ⅳ and Ⅱ₃ wasabout the same,being 22,20 and 18 cases respectively,that in types Ⅱ₁ and Ⅱ₂was much lower,being 4 and 3 cases respectively,and there was none in types Ⅲand Ⅴ.MI also occurred quite frequently in types Ⅳ,Ⅱ₄ and Ⅱ₃ but none intypes Ⅲ and Ⅴ.Furthermore,it was found that both CHD and hypertension were moreclosely related with hyper-β-lipoproteinemia than with hypercholesterolemia andtriglyceridemia.All above results imply that an early discovery and diagnosis of hyper-lipo-proteinemia would be of value to the prevention and treatment of CHD and MI.更多还原