【摘要】 本文就家兔感染日本血吸虫病后所引起的机体反应及组织病理变化的主要发病因子进行了探讨。结果发现家兔在注射40对/8毫升成虫培养液后,除血沉有加速趋势外,血清蛋白组成部分的变化不明显。组织病理变化与家兔感染150条尾蚴后血吸虫产卵前的相似。家兔在注射40—60万虫卵(其中成熟虫卵约占40%)后出现血沉加速,血清白蛋白减少和α、β及γ球蛋白增加。组织病理变化与家兔感染150条尾蚴后5—6周、即虫卵成熟后所引起的酷似。结论认为虫卵、特别是成熟虫卵是血吸虫病发病学中的主要因子,但成虫代谢产物对机体的影响也不容忽视。对血沉与血清蛋白组成变化间及其与组织病理变化间的相互关系及发生机制进行了讨论。更多还原

【Abstract】 The investigations were designed to determine:(1)the changes of the total serum protein,serum electrophoretic pattern and erythrocyte sedimentation rate (ESR)and the time of their occurrence in infected rabbits;(2)the correlation between the change of ESR and serum electrophoretic pattern in the infected rabbits; (3)the relationship between the change of ESR or serum electrophoretic pattern and histopathological pictures in the infected rabbits;and(4)the main role played by schistosoma ova and culture fluid from adult worm in the production of reactive changes in normal rabbits. The result showed that the ESR began to increase on the 5th week after infection. From the 6th to the 12th weeks,the increase continued gradually.Such an increase correlated closely with the histopathological pictures of the liver,such as apparent round cell infiltration and proliferation of the bile ducts in the portal tract.It was presumed that these changes formed the pathological basis of the accelerated ESR. Six weeks after infection,the total serum protein increased from 6.3±0.2g/100 ml to 7.8±0.4 g/100 ml,the serum albumin decreased from 67.7±0.03% to 51.4± 4.5%,the α,β and γ globulin increased from 12.1±0.7%,6.4±1.0% and 13.9± 0.3% to 14.1±2.1%,10.8±1.1% and 23.8±3.8% respectively.The histopatholo- gical changes observed,such as liver cell damage,swelling of Kupffer cell,increase of plasma cells in the liver,spleen and lymph nodes,might be correlated with the altera- tion of serum electrophoretie pattern,as a result of the reduced formation of albumin by the damaged liver cells and also of the increased formation of globulin by the stimulation of the reticuloendothelial system. There was a close correlation between the acceleration of ESR and the decrease of serum albumin or the increase of serum globulin during the whole course of the infection. In the rabbits receiving injections of culture fluid from paired adult worms no significant change except the tendency of an increase in the ESR was observed.In the rabbits receiving injections of schistosoma ova the ESR increased markedly on the following day after injection;the serum albumin decreased from 69.8±3.5% to 55.1±1.1%;the α,α and γ globulin increased from 11.7±1.1%,8.6±1.9% and 10.0±2.5% to 18.6±1.3%,12.2±1.4% and 14.2±2.0% in the 4 days after infection respectively.The histopathological picture in the former group was similar to that observed in experimental schistosomiasis prior to ova deposition;while in the latter group,it was similar to that observed after the maturation of ova. From the above findings,it may be concluded that the mature ova of S.japonicum play an important role in the pathologico-physiological reaction in infected rabbits, while the metabolic products secreted by the paired adult worms should also be taken into consideration.更多还原