【摘要】 已有的资料指出,给去势大鼠注射同化类固醇的最初几天内,提肛肌内糖元含量明显增加。随后提肛肌开始迅速生长,而肌糖元含量逐渐减少。本文研究了同化类固醇对去势或正常大鼠与小鼠的提肛肌或 LBM 重量和对肌糖元含量的影响。结果表明,去势小鼠 LBM 生长速度与所给同化类固醇作用强度和剂量大小有关,但LBM 糖元含量与肌肉生长速度无平行关系。大鼠和小鼠去势后提肛肌和 LBM 重量明显减轻,但糖元含量并不减少。胰岛素和可的松可引起小鼠 LBM 糖元明显增加,但肌肉重量并未增长。MT 刺激小鼠精囊的生长,但精囊的糖元含量反而下降。给去势大鼠注射 TP 后,提肛肌、胫前肌和股直肌糖元含量均有显著增加,然而三种肌肉重量与对照组比较,唯提肛肌重量有显著增加。此外,TP 虽促进大鼠提肛肌的生长,而体外试验表明,给药动物提肛肌利用葡萄糖的能力与对照动物并无显著不同。以上结果似可说明,同化类固醇促进肌肉生长的作用非继发于肌糖元含量的增加。至少可以说,同化类固醇促进糖的利用不是引起肌肉生长的主要条件。更多还原

【Abstract】 The present study was undertaken to define the relationship between the glycogen content changes and the growth of the levator ani muscle induced by anabolic steroids in the rat and the mouse.The results obtained showed that the increase in weight of the levator ani and bulbocavarnosus muscles was closely related to the potency and dosage of the anabolic steroids.However,there was no parallelism between the glycogen content and the amount of growth of the muscles.In castrated rats and mice,a significant increase in weight of the seminal vesicle was elicited by 17-α-methyltestosterone administration,but this increase was not accompanied by a corresponding increase in glycogen content.When the effects of testosterone propionate on the weights and glycogen contents of the levator ani,rectus femoris and tibialis antericus muscles of castrated rats were studed,it was found that testosterone propionate administration resulted in a significant increase in the glycogen content of all three muscles,while only the levator ani of the medicated rats increased significantly in weight.Castration of rats and mice led to a decrease in weight of the levator ani muscle,while the glycogen content of the muscle remained unchanged or even increased.In the intact mice both insulin and cortisone were capable of producing elevation of the glycogen level in the levator ani without inducing growth of the muscle.Besides,in castrated rats testosterone propionate in doses sufficient to induce growth of the levator ani did not affect glucose utilization of the muscle in vitro.更多还原