【摘要】 用比色法测得101只“正常”狗血浆胆硷酯酶(S-ChE)活力的最低值为13.5,最高值52.4,平均值±标准誤为29.9±0.8单位,經統計测驗可认为是常态分布。测得35只高血压狗S-ChE活力的最低值为28.4,最高值49.5,平均值±标准誤为37.1±1.1单位。与“正常”狗比較时,P<0.001,有非常显著差异。其中有12只高血压狗(原发、神經源型及腎型)每天口服蘿芙木硷1—10毫克/公斤共10天,給药前收縮压及舒張压为167.4±3.7及123.8±3.5(毫米汞柱),S-ChE活力为38.74±1.2(单位),服药期間收縮压及舒張压分別下降为131.3±3.8及97.0±3.8,S-ChE活力則同时下降为31.0±1.5。于停药后收縮压及舒張压各为163.8±4.0及123.55±3.7,S-ChE活力为37.8±1.7。高血压狗在服药期間,动脉压和S-ChE活力較給药前及停药后結果有显著降低。有2只腎型高血压狗口服利血平(0.01毫克/公斤)时,也可以看到血压下降同时,出現S-ChE活力的降低。但2只正常狗口服蘿芙木硷(5毫克/公斤)后,并未出現明显的降压作用,其S-ChE也未降低。虽然蘿芙木硷用Warburg測压計法測得結果对S-ChE有直接抑制作用,但作者认为它对S-ChE活力的改变,很可能是与血压状态有关的。更多还原

【Abstract】 Whether there exists a definite relationship between hypertensive states and the activity of serum cholinesterase (S-ChE) remains a problem of controversy. In the present study the S-ChE activity of 101 "normal" and 35 hypertensive dogs was determined by photometric method. The average value (±S. E.)of "normal" dogs is 29.9±0.8 units, which has been shown to be significantly(P<0.001)lower than that of hypertensive dogs, i. e. 37.1±1.1 units. After oral administration of the Rauwolfia alkaloids, 1—10 mg/kg/day, in 12 hypertensive dogs and similarly after reserpine, 0.01 mg/kg/day, in 2 hypertensive dogs the S-ChE activity decreased significantly together with a remarkable fall of the blood pressure. 2 normal dogs receiving the alkaloid 5 mg/kg/day showed neither significant decreases in the blood pressure nor any fluctuation in the activity of S-ChE. The depression of the enzymic activity in hypertensive dogs thus appeared to be correlated with the blood pressure.更多还原