【摘要】 (一)延胡索素乙与环己烯巴比妥钠有协同作用,可以减低小白鼠的被动性和自发性活动;它能对抗小量苯丙胺的兴奋现象,又能明显降低大剂量苯丙胺的毒性反应。它们的有效剂量为20—40毫克/公斤。皮下注射乙素10—30毫克/公斤可使猫先兴奋后抑制,较大剂量对防御性条件反射和非条件反射均能抑制,该作用持续2—3小时以上;腹腔给药时作用情况相似。从侧脑室注射乙素1—2毫克/公斤可使猫消除恐惧跳避的行为,出现瞌睡现象,但易为外界刺激所唤醒。正常家兔的皮层脑电波以低电压快波为主,静脉注射乙素15—20毫克/公斤可使其变成高电压慢波,此时对感应电流刺激皮肤的惊醒反应明显消灭,约历40分钟乙素作用消失。 (二)乙素可使士的宁容易产生惊厥,伹能抑制五甲烯四氮唑的惊厥作用。它不能对抗电休克的发生,略能协同苯妥英钠作用。 (三)乙素略有中枢性的镇吐作用,略能降低体温。更多还原

【Abstract】 (1) In mice, intraperitoneal injection of corydalis B (dl-tetrahydropalmatine), 40 mg/kg, potentiated hexobarbital narcosis, and reduced the passive and spontaneous activity in the rotarod, rolling cylinder and photo-electric cage experiments. The hyperactivity induced by small doses of amphetamine and the amphetamine toxicity in aggregated mice were both significantly reduced by this drug. On the motor defense conditioned reflexes in.cat corydalis B had no marked influence in subcutaneous doses of 10—20 mg/kg. At the dosage of 30 mg/kg, the cats exhibited at first excitant behavior (running, jumping, growling etc.) and then depression set in with almost complete disappearance of conditioned and unconditioned reflexes. At the intraperitoneal dosage of 10 mg/kg, the conditioned reflex was abolished partially, whilst the unconditioned reflex remained unaffected. In cats, an intraventricular injection of corydalis B, 1—2 mg/kg, caused changes in aggressive behavior, such as hissing. The cats became calm and drowsy, but could be easily awaken by external stimuli. In normal rabbits, spontaneous electric activity of cerebral cortex was recorded. The low voltage fast activity was the main element in EEG, sometimes α-wave and spindles were presented. Within 3—7 minutes following single intravenous injection of 15—20 mg/kg, the high voltage slow waves (1.5—3 c/s, 250—400 μv) were found, and maintained 5—15 minutes.. At the same time the arousal response in EEG evoked by stimulation on skin with direct current was inhibited. Thereafter, in the lapse of 20—40 minutes, EEG recovered gradually. (2) In mice, corydalis B aggravated the strychnine convulsions, but inhibited the metrazol convulsions. It had some synergetic action with phenytoin. (3) A single subcutaneous injection of 40 mg/kg of corydalis B could antagonize emesis induced by 0.1—0.2 mg/kg of apomorphine, but failed to do so when the dosage of the latter was raised to 1 mg/kg. The emesis caused by copper sulfate was not antagonized by corydalis B. (4) In rats, corydalis B produced a slight hypothermia.更多还原