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多次注射巴豆油對小鼠感染流行性乙型腦炎病毒的保護性作用
PROTECTIVE ACTION OF REPEATED DOSES OF CROTON OIL IN JAPANESE B ENCEPHALITIS INFECTION OF MICE
【摘要】 <正> 本实验室过去发表的论文指出:在25天的小白鼠皮下注射标准剂量的流行性乙型脑炎病毒(以下简称脑炎病毒)的同天或前一天皮下一次注射5%巴豆油(与石臘油混合)能明显地减低小白鼠的死亡率。目前的实验是:探讨多次注射巴豆油对小鼠感染标准剂量的脑炎病毒后死亡率的影响。从预先的实验发现:如用水剂稀释巴豆油成乳剂状态,其所产生的保护性效应较用油稀释者为大,故在本篇论文中所有实验均采用巴豆油-牛肉汤乳剂。
【Abstract】 During a two week period mice were injected daily with 0.5% croton oil-bacterial broth emulsions. Mortality of the treated animals following Japanese B encephalitis virus infection was significantly reduced. The broth used in the emulsion has no influence on mortality in encephalitis infection. It is thought that the relative insusceptibility of the treated mice is not due to a virucidal or inhibiting action of the oil on the virus. It is suggested that croton oil acts as a non-specific stimulant of the nervous system to induce protective mechanisms either absent or only weakly expressed when such stimulation is not brought into play.
- 【文献出处】 生理学报 ,Acta Physiologica Sinica , 编辑部邮箱 ,1958年02期
- 【被引频次】1
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