【摘要】 <正> 中医学藏象中的“肾”,是祖国医学理论中的重要组成部分。我们以往的工作曾发现在部分肾阳虚病人中,24小时尿17-羟皮质类固醇(以下简称17-羟)含量低于正常,肾上腺皮质对ACTH刺激的应答反应低下或延缓,血浆皮质醇的昼夜变化失去正常节律,这些病人经过较长期的中药治疗后,上述指标在部分病人身上恢复正常,症状亦有更多还原

【Abstract】 Our previous work demonstrated that under certain conditions, some Chinese traditional drugs can modify the activity of the adreno-pituitary system.The negative feedback effect of dexamethasone is known by the fact that feeding the dexamethasone, the plasma concentration of corticosterone is decreased.Our experiments were carrying out in rabbits by feeding the water extracts of three kinds of Chinese traditional; drugs, namely Sheng Di, Zhi Mu and Kan Chao orally for five days either individually or in combination. On the 4th and 5th day of administration, dexamethasone 50μg/kg was given in additon.The plasma] concentration of corticosterone under normal condition was 10.30 ±0.42μg/dl; following dexamethasone alone (control) 2.18±0.42μg/dl; after administration of Chinese traditional drugs, changes insignificant, while with dexamethasone in addition 6.60±0.48μg/dl.Therefore it was sure that these Chinese traditional drugs can reduce the negative feedback effect of dexamethasone. All of th figures were statistically significant.更多还原