【摘要】 <正> 出血综合征是急性放射病极期的一个严重症状,也是死亡原因之一。关于其发病机理,至今仍不太清楚。根据各学者的意见,大致可将其归纳为以下三个方面:(1)照后骨髓巨核细胞及血管床内血小板质与量的变化;(2)血管壁内皮及其各层损伤致使小血管损伤的可能性增强,抗力降低,造成血管机能改变;(3)血凝固系统障碍,特别是微循环障碍,致使血凝过程恶化。但仅用上述因素很难完全解释放射病的出血倾向,因为出血症状与以上各因素在发生时间上似并不完全一致。更多还原

【Abstract】 The whole blood serotonin (hydroxytrypamine,5-HT)was determined in experimental dogs suffering from acute illness by radiation with 265 rad. The method of determination was according to Maickel’s, by the formation of fluorescent derivatives with ortho-phthalaldehyde (OPT), but modified by using the blood sample of 0.5 ml instead of 2ml. The serotonin in the clear supernatant was placed on the microglass and examined under fluorescence spectrophotometer, Hitachi MPF-4, made in Japan.The results of the experiments revealed that the normal level of blood serotonin (0.46±0.07y/ml) was inclined to decrease on the 3rd day after radiating exposure, quite obvious on the 10th day and reached the minimium at the 16th day. By the meantime hemorrhage was usually apparent and quite frequent. The tendency of hemorrhage was as a rule kept in parallel with the decreasing of thrombocyte count. The survival dogs gradually had their blood serotonin returned to normal after 4 or more weeks.更多还原