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掌叶半夏抗子宫颈癌成分的研究——(Ⅰ)胡芦巴碱的分离和鉴定

STUDIES ON THE ANTITUMOR PRINCIPLES FROM THE CHINESE DRUG PINELLIA PEDATISECTA Ⅰ. THE ISOLATION, IDENTIFICATION AND CLINICAL EXAMINATION OF THE TRIGONELLINE

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【Author】 LIU XING-JIE LIN YUN-FU(Department of Chemistry of Natural Products, Faculty of Pharmacy, Shanghai First Medical College, Shanghai)XU YA-MING(Gynecological and Obstetrical Hospital, Shanghai First Medical College, Shanghai)DING SHENG-SONG(Department of Chemistry, Faculty of Basic Medical Sciences, Shanghai First Medical College, Shanghai)

【机构】上海第一医学院药学系天然药化教研组；上海第一医学院妇产科医院；上海第一医学院基础医学部化学教研组；

【摘要】 <正> 1970年我院妇产科在浙江农村调查中发掘掌叶半夏（Pinellia Pedatisecta Schott）（原名天南星）的抗癌作用以后,为了提高疗效并消除其副作用,改进剂型制出宫颈栓剂,经临床多年来的使用证实掌叶半夏确有抗子宫颈癌疗效,其稀醇或水浸出液对动物实验肿瘤(S-180、HCA及U₁₄各瘤株)和Hela细胞都具有明显的抑制作用。更多还原

【Abstract】 An antitumor principle of the Chinese drug, Pinellia pedatisecta Sohott was obtained by fractionating the total water soluble alkaloids of the plant on ion exchange resin and aluminium oxide columns successively. The structure of this principle was identified to be trigonelline by spectra (i.e. IE and NMK) and confirmed by comparison to a pure synthetic product. The tumor-inhibiting effect of trigonelline was examined on experimental tumor exhibited a marked inhibting action on hepatic carcinoma (mouse). The therapeutic effect of clinical trial in detail was published elsewhere.更多还原

【关键词】掌叶半夏；胡芦巴；瘤株；动物实验；抑制作用； Pinellia； Schott；抑瘤作用；急性毒性；红外光谱；

【文献出处】上海第一医学院学报 , 编辑部邮箱 ,1979年04期

【被引频次】11
【下载频次】266

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