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纳洛酮对针刺抑制家兔大脑皮层牙髓诱发电位的影响

The Effect of Naloxone on the Inhibitory Action of Electro-acupuncture upon Cortical Potentials Evoked by Tooth Pulp Stimulation in Rabbits

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【作者】 程介士叶志钧欧淑培

【Author】 Acupuncture Anesthesia Research Group,Faculty of Basic Medical Sciences, Shanghai First Medical College, Shanghai

【机构】 上海第一医学院基础医学卩针麻研究组上海第一医学院基础医学卩针麻研究组

【摘要】 <正> 关于针刺穴位能抑制牙髓刺激引起的大脑皮层诱发电位,已有不少报导。目前,国内不少作者倾向于认为大脑皮层牙髓诱发电位在一定程度上能反映疼痛。因此,我们在研究脑内阿片受体与针刺镇痛的关系时,除以动物行为作指标,进行针刺镇痛实验外,亦试图以大脑皮层牙髓诱发电位为指标进行观察。

【Abstract】 The present work was carried out on rabbits anesthetized by urethane and chloralose. Cortical potentials evoked by stimulating tooth pulp were recorded from the somatosensory area. When "Ho-Ku" (合谷) and "Nei-Kuan"(内关) points were electrically needled or when morphine (1.5-4.0 mg/kg ) was intravenously administered, the evoked potentials were markedly depressed manifesting a decrease in the amplitude of the primary response to 71% or 75 % of the control value respectively. As a comparison, potentials evoked by stimulating the kinfra-orbital nerve recorded from the same site of the cortex,were only slightly affected by needling or by morphine, with a decrease in primary response to 92% or 98.5% of the control value respectively . Thus the evoked potentials by tooth pulp stimulation were more susceptible to morphine and electro-acupuncture.To examine the effect of morphine antagonist-naloxone on the inhibitoryaction of electro-acupuncture, 0.4mg/kg of naloxone was given intravenously to rabbits prior to needling. The result was that the depression of evoked potentials by tooth pulp stimulation was significantly reversed (P<0.01). The reversal was 36% of the entire value reduced by needling.The result suggests that the inhibitory action of electro-acupuncture upon evoked potentials by tooth pulp stimu-lation is partially related to the activity of opiate receptors and the morphine-like substances.

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