【摘要】 <正> 防己碱系自中药清风藤中提出的有效成分,该药初称清风藤碱甲或清藤碱,经鉴定知即为 Sinomenine。由于清风藤经植物鉴定为防己(Sinomenium acutum),而且又是防己科防己属的仅有一种,故该药现亦名为防己碱。防己碱的镇痛作用几经研究,张士善等及我组都用小鼠热板法证明对痛阈具有提高作用;但左玉娥等用小鼠电刺激法发现其镇痛作用极为微弱,而早年文献中亦有完全缺乏镇痛作用的记载。由于目前所用各种镇痛实验方法,均有一定局限性,为此我们再采用小鼠电更多还原

【Abstract】 Confirmatory to our previous result with the analgesic effect of sinomenine as assessed in mice by the hot plate method,we found that it could likewise elevate the pain threshold of mice and rabbits as assessed by the electrical stimulation method and the radiant heat stimulation method, respectively. Sinomenine administered into the lateral ven- tricles in rabbits was also effective in raising the pain threshold in doses smaller than 1/3000 of the effective intravenous dose.This gives further experimental support to our previous supposition that the analgesic action of sinome- nine is central in origin rather than peripheral through histamine depletion as suggested by Jap- anese workers.更多还原