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痢疾菌苗动物实驗性免疫的研究
Laboratory Studies on the Effect of Dysentery Vaccine
【摘要】 <正> 我们于1955年10月至1956年3月會进行了关于痢疾菌苗的动物免疫试验,主要的目的在于解决痢疾菌苗的反应问題,我们试验了用酒精脫毒的方法,未能达到脱毒的目的,而发现应用菌体加热至80℃經1小时后的过滤液,在小白鼠试验中,可以产生与加热菌苗相近的免疫力,而局部反应則較加热菌苗大为减輕。但对于这种細菌滤液的免疫强度究竟如何,持续多长时间等问題未作进一步的试
【Abstract】 The effect of active immunization with heat killed dysentery vaccine, saline extract of dysentery bacilli and extract of dysentery bacilli after freezing and sawing was compared. It was found that both saline extract and after freezing and sawing was much inferior than heat killed vaccine as judged by mouse protection test. Although heat killed dysentery vaccine conferred immunity against dysenteW bacilli on experimental mice, it does not protect monkeys against dysentery as reported by workers in U. S. S. R., we feel that further studies of the effect of dysentery vaccine on susceptible animals are required.
- 【文献出处】 上医学报 , 编辑部邮箱 ,1959年06期
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