【摘要】 <正> 自wara等报告鼻咽癌患者血清中免疫球蛋白 A(IgA)升高后,Henle等用间接免疫荧光试验证实这种IgA抗体对EB病毒是特异性的。我们的研究结果也证实了这点。测定EB病毒特异性壳抗元IgA抗体(VCA-IgA)对于鼻咽癌的诊断和作为预后的指标是很更多还原

【Abstract】 Serum anti-EBV-IgA antibodies （EBV-IgA） in NPC patients were determined at a single-cell level by immuno-radioautography, using ¹²⁵I-labelled rabbit or horse antihuman IgA antibodies. The assay proves sensitive, specific and easily repeatable. The optimal quantity of radiation ¹²³I for labelling was found to be 10 μ Ci/μg protein/ml. Sera from patients of malignant cases of carcinoma, including NPC, and from normal persons have been exa mined by this method. GMT’s of EBV-IgA antibodies are 1 : 3, 259 for NPC patients; 1 : 7.09 for other cancer patients, and 1:3.16 for normal controls respectively. The antibody titers in all normal individuals read 1:160 or less. A titer higher than 1:640 is considered positive. The positive rates for these above three groups of individuals are 97.3%, 1.67% and 0% respectively. Their differences are very prominent. This assay is more sensitive than fluorescence examination and can be used in NPC diagnosis. It is especially useful for mass screening in regions where carcinoma incidence rate is high.更多还原