【摘要】 本文主要報告α-苯基-β-(3,5-二碘-4-羥苯基)-丙酸的詳細合成方法。所得產品毒性較舶來品稍低,在X射線下不透光度很大,適合臨床上胆囊造影之用。實驗過程中,曾以氫碘酸及紅磷還原對甲氧基-α-苯代肉桂酸,未獲成功。但此還原反應在鈉汞齊作用下,可以順利進行。更多还原

【Abstract】 A detailed procedure, which is essentially a modification of Baker and Briggs’ method, is described here for the synthesis of α-phenyl-β-(3,5-diiodo-4-hydroxy-phenyl)-propionic acid (Priodax). Two derivatives of Priodax, one ,being new, were also prepared. The Priodax obtained exhibits low toxicity and produces good cholecystographic shadows. An attempt was made to employ hydriodic acid and red phosphorus for the simultaneous reduction and demethylation of p-methoxy-a-phenylcinnamic acid without success. How- ever, this substituted cinnamic acid can be reduced in good yield by means of sodium amalgam.更多还原