【作者】 刘军；

【导师】 李凌江；

【作者基本信息】 中南大学 ， 精神病学与精神卫生， 2009， 博士

【摘要】 第一部分功能性磁共振实用反应收集系统的研制目的：研制简易实用功能磁共振实用反应收集系统,进行功能磁共振操作过程中任务输入与输出。方法：采用4芯屏蔽连接线及PVC材质的按键盒及控制盒,信号传输采用I0通讯方式,结合电脑及Presentation软件,进行任务输入与输出。结果：采用该实用反应收集系统均顺利完成了实验,所得结果可靠。结论：功能磁共振实用反应收集系统简单实用,可以满足临床及科研脑功能磁共振的基本需要,在没有购置视听刺激转换系统的单位,值得普及推广。第二部分基于ReHo方法的IAD大学生静息脑功能磁共振成像研究目的：采用ReHo分析方法,探讨静息背景下网络成瘾大学生的脑功能特点。方法：在静息背景下,19名网络成瘾大学生及19名对照进行磁共振脑功能成像,采用ReHo分析方法,比较两组平均脑ReHo图的差异。结果：IAD组ReHo值升高区域主要集中在以下几个部位：小脑、脑干、扣带回(右侧)、双侧海马旁回,右侧额叶(直回,额中回及额下回),左侧额上回,左侧楔前叶,右侧中央后回,右侧枕中回,右侧颞下回,左侧颞上回及颞中回；ReHo降低的区域仅表现在左侧顶叶的楔前叶。结论：网络成瘾大学生与正常对照大学生局域一致性存在异常,大部分脑区同步性增强,这些结果反应了网络成瘾大学生脑功能的改变,小脑、脑干、边缘叶、额顶叶同步性增强可能与奖赏通路有关。第三部分基于任务刺激IAD大学生脑功能成像磁共振研究目的：利用任务背景刺激功能磁共振方法,探讨网络成瘾大学生的脑功能特点。方法：以网络游戏内容作为实验刺激任务,采用组块设计方法,对19名网络成瘾大学生及19名对照进行磁共振脑功能成像,对两组被试的脑功能分别予以组内和组间分析,得出两组在观看网络游戏录像时平均脑功能激活图,并分析比较两组脑区激活的差异。结果：19例网络成瘾者及19例正常对照均得到显著激活,正常对照组激活主要出现在右侧额上回、额中回、额下回、左侧颞叶脑岛叶、右侧顶叶楔前叶。IAD组激活主要出现在右侧额内侧回、额中回、额上回、双侧颞上回、左侧颞横回、左侧颞上回、右侧顶下回、右侧顶下小叶、右侧顶叶楔前叶、右侧小脑后叶。IAD较正常对照增强激活的脑区有右侧顶上小叶,右侧颞叶脑岛,右侧顶叶楔前叶,右侧扣带回,右侧颞上回,左侧脑干,并出现部分脑区的负激活。结论：网络游戏任务刺激均引起正常及网络成瘾者视空注意及执行中枢的激活,颞枕及额顶叶皮质组成脑视空注意及执行中枢；网络成瘾者存在脑功能异常,可能存在额叶功能低下；网络成瘾者存在右侧大脑偏侧化激活现象。第四部分IAD大学生脑磁共振波谱分析目的：利用磁共振波谱分析方法,探讨网络成瘾大学生脑波谱特点。方法：采用多体素波谱分析方法,对14名网络成瘾大学生及14名对照进行磁共振脑功能波谱成像分析,选取双侧额叶及脑干,得出NAA, Cr, Cho等代谢物的相对浓度,并在此基础上计算NAA/Cr, Cho/Cr的比值。结果：结果显示IAD组双侧额叶NAA峰减低,NAA/Cr及Cho/Cr比值与对照组有显著性差异(P<0.01), IAD双侧脑干与对照组NAA/Cr及Cho/Cr比值无显著性差异(P>0.05)结论：网络成瘾者可能存在额叶神经元功能的异常或者部分神经元的丢失。某种程度上可能存在神经元细胞膜功能受损或者信号传导异常。更多还原

【Abstract】 Part I The invention of practical response and collection system using in fMRIObjective To invent a practical response and collection device to accomplish input and output of tasks in functional magnetic resonance imagingMethods Apply 4 core lines of attachment with key set box and control box of PVC texture to carry out input and output of tasks, which combined with computer and presentation software.10 communication mode is used to signal transmission.Results By using this practical response and collection device, we successfully completed various experiments of fMRI and the results were reliable.Conclusion The practical response and collection system of fMRI is easy and useful. It can meet the basic needs of clinic and scientific research. It is worth of popularity and generalization in units which have not visual and auditory stimuli commutation system.PartⅡResting fMRI study of IAD college students based on method of ReHo analysisObjective Regional homogeneity (ReHo) method was used to analyze possible cerebral functional characteristics of IAD college students under the resting state.Methods The subjects included 19 IAD college students and 19 matched healthy controls. Functional magnetic resonance image (fMRI) was obtained on a Siemens 3.0-Tesla Trio Tim scanner with high-speed gradients. Regional homogeneity (ReHo) method was used to analyze the differences of cerebral functional characteristics between two groups under resting state. Results The following increased ReHo brain regions were found in IAD group compared with the control group:cerebellum, brainstem, right cingulate gyrus, bilateral parahippocampus, right frontal lobe(rectal gyrus, inferior frontal gyrus and middle frontal gyrus), left superior frontal gyrus, left precuneus, right postcentral gyrus, right middle occipital gyrus, right inferior temporal gyrus, left superior temporal gyrus and middle temporal gyrus. The decreased ReHo was only found in left precuneus.Conclusion Abnormal brain activity of IAD college students may exist in a resting state compared with the control group. It was concluded that there are enhancements of synchronization among cerebellum, brainstem, limbic lobe, frontal lobe, apical lobe which related to reward pathways in IAD college students.Part III Functional MRI study based on task of IAD college studentsObjective To explore the functional locations of brain regions related to internet addition with task-functional magnetic resonance imaging.Methods 19 college students who had internet game addition and 19 controls accepted the stimuli of videos via computer, while the 3.0 Tesla MRI was used to record the results of echo plannar imaging. The block design method was used. Intragroup and intergroup analysis results in two groups had gotten. The differences between the two groups were analyzed.Results The internet game videos markedly actived the brain regions of the college students who had or had no internet game addiction. The actived brain regions of the controls including right superior frontal gyrus, right middle frontal, right inferior frontal gyrus, left insular lobe and right precuneus. IAD group showed actived brain regions that mainly distributed over right medial frontal gyrus, right middle frontal gyrus, superior frontal gyrus, bilateral superior temporal gyrus, left transverse temporal gyrus, right inferior parietal gyrus, right inferior parietal lobule, right precuneus, right posterior lobe. Compared with the control group, IAD group showed increased activation in right superior parietal lobule, right insular lobe, right precuneus, right cingulated gyrus, right superior temporal gyrus, left brainstem and some decreased activation brain regions.Conclusion Internet game tasks can active the vision, space, attention and execution center which are composed of temporal occipital gyrus and frontal parietal gyrus. Abnormal brain function may be exist in IAD and frontal cortex may be hypofunction. IAD group show laterality activation of right brain.Part IV An 1H-MRS study of IAD college studentsObjective To study cerebral spectroscopy characteristics of IAD college students by using 1H-proton magnetic resonance imaging.Methods Chemical shift image 1H-MRS examinations in bilateral frontal lobe and brainstem were acquired from 14 healthy volunteers (control group) and 14 cases (patient group) with IAD. The relative concentrations of NAA, Cr, and Cho were observed and the ratios of NAA/Cr and Cho/Cr were evaluated.Results IAD group showed descended the peak of NAA and ascended the peak of Cho. NAA/Cr and Cho/Cr levels in bilateral frontal lobe of IAD group showed markedly statistical difference compared with the control group (P<0.01). There were no statistical difference of NAA/Cr and Cho/Cr levels in bilateral brainstem of the two groups (P>0.05)Conclusion IAD group may be abnormal function with frontal lobe or loss of partial neurons. To a certain extent, cell membrane function of neurons may be damaged or signal transduction may be abnormal.更多还原