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大鼠脑内星形胶质细胞和神经元在正常或模拟失重状态下对血压变化的反应及其相互关系的形态学研究

Morphological Study on Response and Relationship of Neurons and Astrocytes to Changes of Blood Pressure in Normal and Simulated Weightlessness Rats

【作者】 宿长军

【导师】 饶志仁;

【作者基本信息】 第四军医大学 , 神经生物学, 2000, 博士

【摘要】 第一部分 已知孤束核(NTS)、延髓腹外侧区(VLM)、A5区、结合臂旁核(PB)、兰斑(LC)、中脑导水管中央灰质(PAG)、下丘脑室旁核(PVN)、视上核(SON)、杏仁中央核(Ce)以及边缘皮质等结构参与心血管调节,但哪些结构对血压变化反应敏锐,在高、低血压对有何不同,哪些结构参与压力感受器反射报道不一。抗Fos蛋白的免疫组织化学方法是目前常用的机能形态学方法之一,用以了解与某机能相关的神经元在中枢神经系统内的分布。 星形胶质细胞(AS)被认为是对神经元起支持、营养和保护功能,但随着研究技术和方法的不断进步,越来越多的证据表明,AS并非惰性细胞,而是与周围神经元之间存在双向通讯,可通过改变细胞外空间神经活性物质的浓度或通过控制神经元的微环境来调制神经元的活动。 本研究利用静脉注射硝普钠或苯肾上腺素制作瞬间低血压和高血压模型,用免疫组织化学的方法系统观察了大鼠脑内Fos蛋白表达的情况,以及与TH阳性神经元的关系,从整体水平了解中枢参与血压反射性调控部位的全貌;同时观察GFAP表达的变化,并结合与抗Fos和抗酪氨酸羟化酶(TH)三

【Abstract】 Part OneIt is well known that certain nucleus of the brain, e, g NTS, VLM, PB, LC, PAG, PVN, SON, Ce and limbic cortex are involved in the modulation of cardiovascular activities. How these structures responde to the blood pressure changes and whether they take part in the baroreflex, however, are still not well understood. The expression of Fos like protain is regarded as one marker of neuronal activation, and it can be succesfully used to investigate the distribution of neurons responded to the specific stimulation in the CNS.On the other hand astrocytes is a very important element in CNS. Recent evidences have shown that astrocytes were not only play roles in but communicate with the neurons and modulate the excitatory activaty of the neurons through changing the concentration of extracellular neural active substance or controlling the microenvironment as well.

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