【作者】 李晓辉；

【导师】 宋跃明；

【作者基本信息】 四川大学 ， 外科学， 2006， 博士

【摘要】 目的：设计制备适合于山羊颈椎前路减压融合的颈椎间融合器PDLLA Cage，通过有限元分析，体外生物力学和体内维持稳定和成骨作用的观察评价，以探讨其对颈椎间融合的生物学和生物力学作用。 方法：(1) 设计制备PDLLA Cage，并进行力学检测。(2) 有限元分析：建立山羊颈椎C3-4融合术后三维有限元模型，并对其进行生物力学模拟。选取一只雌性成年山羊，进行影像学检查和临床查体排除脊柱疾患后，行螺旋CT扫描，得到的连续断层数据图片以DICOM格式输出，导入医学三维重建软件MIMICS，经过图片的筛选，预处理，提取边界的坐标值，生成表面三维图像，再将此图像通过ABAQUS软件生成三维实体，同时建立PDLLA Cage和三面皮质髂骨实体，然后将其组合。进行网格划分，赋予材料力学参数，构建出PDLLA Cage和三面皮质髂骨两种颈椎C3-4融合术后三维有限元模型。预载荷20N，再加以1.0 Nm的纯力矩模拟前屈、后伸、左／右侧曲、旋转活动，观察两种融合术后脊柱功能单位(functional spinal unite，FSU)的载荷-位移关系，比较ROM和平均刚度。并与体外生物力学实验结果比较。(3) 体外生物力学研究：比较PDLLA Cage、钛合金Cage和三面皮质髂骨三种内植物植入山羊颈椎C3-4后的生物力学行为。27只羊颈椎标本随机分为4组，A组：正更多还原

【Abstract】 Objective: The purpose of this study was to design a type of PDLLA Cage, establish the cervical three-dimensional finite element model of the goat C3-4 cervical spine treated with anterior decompression and body fusion, discuss the biomechanics alternation of the Functional Spinal Unit (FSU), investigate the immediate stability of different fusion methods, evaluate biomechanical effect of PDLLA Cage in vitro, and compare the characteristics of inter body fusion using PDLLA Cage with those of titanium Cage and autologous tricortical iliac crest graft in a goat cervical spine model in vivo.Methods: (1) In this part of study, a type of PDLLA Cage was designed and made, and the biomechanical behavior analysis about the materials was performed. (2) Finite element analysis: One healthy adult female goat which had been proved no any spinal disease by radioactive examination was selected. Undertaking CT scan with 0.5mm thickness, the data of CT imaging was taken and saved with DICOM format. After the CT imaging was processed with MIMICS software, the superficial 3D imaging and its boundary coordination was achieved. Using the ABAQUS software, the C3-4 body 3D entity, the PDLLA Cage entity, and the tricortical iliac crest bone graft was created respectively. And then packing these entities together, two更多还原